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Stem cells and tissue rejection
Tissue rejection in stem cells?
Im doing an essay on the ethics of stem cell reserach and I'm exploring the different origins of stem cells. I know that in adult stem cells tissue rejection is an issue as well as with cord blood stem cells.

However, can human embryonic stem cells be transplanted into any person (I think they can but I cannot see how)? And if so, why is tissue rejection not a problem since even at this early stage cells will still contain DNA?

Thank you for your help with this - no one/nothing seems to know the answer!

Aimee
x
asked in medicine, science, stem cells



cryptminder answers:

One way to avoid the problem of rejection is to use stem cells that are genetically identical to the host.

This is already possible in the rare situations when the patient has healthy stem cells in an undamaged part of the body (like the stem cells being used to replace damaged corneas).

But even where no "autologous" stems cells are available, there may be a solution: using somatic-cell nuclear transfer (but with no goal of attempting to implant the resulting blastocyst in a uterus).
In this technique,

A human egg has its own nucleus removed and replaced by
a nucleus taken from a somatic (e.g., skin) cell of the patient.
The now-diploid egg is allowed to develop in culture to the blastocyst stage when
embryonic stem cells can be harvested and grown up in culture.
When they have acquired the desired properties, they can be implanted in the patient with no fear of rejection.
On 11 November 2007, scientists in Oregon reported success with steps 1–4 in rhesus monkeys. While this increases the probability of being able to apply the procedure to humans, there are still questions with the method that must be answered.

Take a look at this paper#
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Stem_Cells.html


More information can be seen here#


Embryonic Stem Cells Could Help Overcome Immune Rejection Problems
http://www.sciencedaily.com/releases/2008/04/080411082935.htm


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